The Cuyahoga River in Ohio is famous to anyone who has studied the history of the environmental movement in the United States. Outside Magazine published a great article about the river in 2020, recounting its pivotal role in the history of the Clean Water Act, and describing ongoing efforts to clean up the river.
Here is a map of the Cuyahoga watershed using data from the US Geological Survey. I recently added this as a new data source option in the Global Watersheds mapper.